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| 论文编号: |
O120090055 |
| 第一作者所在部门: |
610组 |
| 中文论文题目: |
Controllable release of ibuprofen from size-adjustable mesoporous silica spheres
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| 英文论文题目: |
Controllable release of ibuprofen from size-adjustable mesoporous silica spheres
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| 论文题目英文: |
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| 作者: |
徐武军 高 强 徐 耀 吴 东 孙予罕 沈万凌邓 凤
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| 论文出处: |
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| 刊物名称: |
Powder Technology
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| 年: |
2009
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| 卷: |
191 |
| 期: |
1-2 |
| 页: |
13-20 |
| 联系作者: |
徐 耀 |
| 收录类别: |
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| 影响因子: |
1.766
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| 摘要: |
Mesoporous silica spheres with controllable particle size were synthesized in mixed ethanol–water solvent.
These materials possessed same pore size distribution and pore channel geometry. The amount of
ibuprofen (IBU) adsorbed in mesoporous channels increased with the surface area of mesoporous silica
spheres. Three kinds of release fluids, simulated intestinal fluid (SIF, pH=7.4), simulated body fluid (SBF,
pH=7.4), and simulated gastric fluid (SGF, HCl aqueous solution, pH=1.2) were used to investigate drug
release. The effects of particle size and dispersancy of mesoporous spheres on drug release rate were
discussed in detail. It was found that larger or agglomerate mesoporous silica spheres could delay the drug
release process, which could be attributed to pore-mouth amount and mesopore channel length of
mesoporous spheres. Furthermore, to obtain a well controlled drug release system, hydrophobic
trimethylsilyl (TMS) groups were functionalized on the surface of mesoporous silica spheres. The release
of IBU from TMS-functionalized mesoporous spheres was obviously delayed with the increase of TMS
content. |
| 英文摘要: |
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| 外单位作者单位: |
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| 备注: |
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关闭窗口 |
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