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| 论文编号: |
O120090054 |
| 第一作者所在部门: |
610组 |
| 中文论文题目: |
pH-Controlled drug release from mesoporous silica tablets coated with hydroxypropyl methylcellulose phthalate
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| 英文论文题目: |
pH-Controlled drug release from mesoporous silica tablets coated with hydroxypropyl methylcellulose phthalate
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| 论文题目英文: |
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| 作者: |
徐武军 高 强 徐 耀吴 东 孙予罕
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| 论文出处: |
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| 刊物名称: |
Materials Research Bulletin
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| 年: |
2009
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| 卷: |
44 |
| 期: |
3 |
| 页: |
606-612 |
| 联系作者: |
徐 耀 |
| 收录类别: |
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| 影响因子: |
1.812
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| 摘要: |
A simple pH-controlled drug release system was successfully prepared by coating pH-sensitive polymer
hydroxypropyl methylcellulose phthalate (HPMCP) on drug-loaded mesoporous SBA-15 tablet. Using
famotidine (Famo) as a model drug, the effects of coating times and drying temperature on drug release
were studied in detail to optimize the drug release system. In simulated gastric fluid (SGF, pH 1.2), it took
only 2 h for Famo to be completely released from mesoporous silica tablet without HPMCP coating. Also
in SGF, with the increase of coating times and drying temperature, the release of Famo was greatly
delayed by HPMCP coating. For the tablet with twice coating of HPMCP and dried at 80 8C, only 4.0 wt.% of
Famo could be released within 4 h. However, in simulated intestinal fluid (SIF, pH 7.4), HPMCP coating did
not show obvious effect on the release of Famo. |
| 英文摘要: |
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| 备注: |
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