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| 论文编号: |
O120090050 |
| 第一作者所在部门: |
610组 |
| 中文论文题目: |
pH-Responsive Drug Release from Polymer-Coated Mesoporous Silica Spheres
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| 英文论文题目: |
pH-Responsive Drug Release from Polymer-Coated Mesoporous Silica Spheres
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| 论文题目英文: |
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| 作者: |
高 强 徐 耀 吴 东孙予罕 李小安
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| 论文出处: |
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| 刊物名称: |
Journal of Physical Chemistry C
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| 年: |
2009
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| 卷: |
113 |
| 期: |
29 |
| 页: |
12753–12758 |
| 联系作者: |
徐 耀 |
| 收录类别: |
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| 影响因子: |
3.396
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| 摘要: |
A novel method was proposed to coat poly(methacrylic acid-co-vinyl triethoxylsilane) (PMV) on mesoporous
silica spheres (MSSs) to obtain a core-shell pH-responsive drug-carrier (MSS/PMV). PMV was prepared by
free radical polymerization of methacrylic acid (MAA) and vinyl triethoxylsilane (VTES), in which MAA
acted as the pH-sensitive monomer and VTES acted as the siloxane-containing monomer to provide an
anchoring effect with the MSS surface. The micrographs of MSSs before and after coating were investigated
by transmission electron microscopy (TEM) and scanning electron microscopy (SEM). It was found that the
PMV shell with a thickness of 20 nm had been coated successfully on MSS particles. To confirm the pHsensitivity
of the PMV shell, we investigated the pH-response difference between MSS/PMV and MSS/
PMV-H (acidified MSS/PMV) in NH4NO3/C2H5OH solution. It was found that the PMV shell of MSS/PMV
was loose (“open” state) and allowed template molecules to penetrate it easily. By contrast, the PMV shell
of MSS/PMV-H was compact (“closed” state) and confined template molecules effectively inside MSS pores.
These results indicated that the PMV shell played the role of molecular switch that could control the transport
of molecules via a pH-dependent “open-close” mechanism. In a test of in vitro drug release, MSS/PMV
showed high response to the pH of a drug solution. At high pH (pH ) 7.5), ibuprofen (IBU) that loaded in
MSS/PMV released rapidly and completely (within 2 h); at low pH (pH ) 4.0 or 5.0), only a small part of
the IBU (15 wt %) was slowly released from the MSS/PMV, and most of the IBU was effectively confined
in MSS pores. |
| 英文摘要: |
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| 备注: |
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