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| 论文编号: |
122214O120110071 |
| 第一作者所在部门: |
610组 |
| 中文论文题目: |
板状氨基/甲基双官能化SBA－15用于胆红素吸附
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| 英文论文题目: |
Bilirubin adsorption on amine/methyl bifunctionalized SBA-15 with platelet morphology
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| 论文题目英文: |
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| 作者: |
徐耀
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| 论文出处: |
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| 刊物名称: |
Colloids And Surfaces B-Biointerfaces
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| 年: |
2011
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| 卷: |
84 |
| 期: |
2 |
| 页: |
571 |
| 联系作者: |
徐耀 |
| 收录类别: |
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| 影响因子: |
2.78
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| 摘要: |
To remove bilirubin from human plasma, amine/methyl bifunctionalized SBA-15 materials were directly synthesized from the co-condensation of 3-aminopropylmethyldiethoxysilane and tetraethoxysilane with an amphiphilic block copolymer P123 as template. XRD,N2 sorption analysis, FTIR and 29SiMASNMR
were used to identify their well-ordered mesostructure and the grafting of amine and methyl groups on the surface of as-synthesized materials. Both SEM and TEM indicated that the bifunctionalized SBA-15 possessed platelet morphology. This might be attributed to the charge repulsion brought by protonated amine groups and the diminution of hydroxyl groups on the end of silicate-micelles, which passivated the end-to-end anchoring of silicate-micelles along the longitudinal axis. Such a material was investigated
as the adsorbent for selective bilirubin removal from human plasma, which showed a high bilirubin clearance of 51.4% within 1.5 h with a little amount of albumin adsorption. The results of hemolysis assay suggested that the bifunctionalized SBA-15 caused serious hemolysis of red blood cells. However, in practical application, plasma separation technique could avoid direct contact between the adsorbent and red blood cells. The further hemeolysis assay proved that the plasma after contacting with the bifunctionalized
SBA-15 could not lead to the hemolysis of red blood cells. Thus, the bifunctionalized SBA-15 is expected to be a potential candidate as a clinical hemoperfusion material. |
| 英文摘要: |
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