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| 论文编号: |
122214O120120172 |
| 第一作者所在部门: |
608组 |
| 中文论文题目: |
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| 英文论文题目: |
Preparation of Drug Nanoparticles Using a T-Junction Microchannel System
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| 论文题目英文: |
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| 作者: |
张乾霞 Li-Min Xu Yue Zhou *Jie-Xin Wang Jian-Feng Chen
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| 论文出处: |
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| 刊物名称: |
Industrial &Engineering Chemistry Research
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| 年: |
2011
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| 卷: |
50 |
| 期: |
24 |
| 页: |
13805 |
| 联系作者: |
张乾霞 Li-Min Xu Yue Zhou *Jie-Xin Wang Jian-Feng Chen |
| 收录类别: |
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| 影响因子: |
2.237
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| 摘要: |
Cefuroxime axetil (CFA) drug nanoparticles are prepared by liquid antisolvent precipitation in a microchannel system with a T-shaped junction formed by a main microchannel and a branch. Isopropyl ether as antisolvent (large flow rate) was usually passed through the main microchannel, while CFA acetone solution as solvent (small flow rate) was injected into the branch simultaneously. The solvent diffused from the CFA acetone solution stream into the antisolvent phase, which resulted in the supersaturation of CFA and thus led to the rapid precipitation of CFA nanoparticles. The change of the injection phase from CFA acetone solution to isopropyl ether was found to have a significant effect on the formation of CFA nanoparticles owing to the different contact behavior. The morphology and the size of CFA nanoparticles were characterized by scanning electronic microscope (SEM) and particle size distributions (PSD) by laser diffractometer. Furthermore, the effects of CFA acetone solution velocity, antisolvent velocity, overall velocity and CFA concentration, on particle size and size distribution were experimentally investigated. The as-prepared CFA nanoparticles were amorphous and exhibited higher dissolution rate compared to the raw CFA and commercial product. This work suggests that microfluidics may find wide applications for the development and optimization of drug nanoparticles in the newly emerging field of nanomedicine. |
| 英文摘要: |
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