|
|
| 论文编号: |
122214O120120170 |
| 第一作者所在部门: |
608组 |
| 中文论文题目: |
|
| 英文论文题目: |
Engineering drug ultrafine particles of beclomethasone dipropionate for dry powder inhalation
|
| 论文题目英文: |
|
| 作者: |
Li-Min
|
| 论文出处: |
|
| 刊物名称: |
International Journal of Pharmaceutics
|
| 年: |
2012
|
| 卷: |
436 |
| 期: |
1 |
| 页: |
1-9 |
| 联系作者: |
|
| 收录类别: |
|
| 影响因子: |
3.35
|
| 摘要: |
Beclomethasone dipropionate (BDP), which is a member in the inhaled glucocorticosteroid class, is commonly used in the treatment of asthma by pulmonary delivery. The purpose of this study is to prepare ultrafine BDP particles for dry powder inhalation (DPI) administration by combining microfluidic antisolvent precipitation without surfactant, high-pressure homogenization (HPH) and spray drying. T-junction microchannel was adopted for the preparation of needle-like BDP particles. The needle-like particles could be easily broken down into smaller particles during HPH, which were assembled into uniform low-density spherical BDP aggregates by spray drying. The effects of the operation parameters, such as the flow rates of BDP methane solution and antisolvent, the overall flow rate, the BDP concentration, and the change of the injection phase on BDP particle size were explored. The results indicated that the BDP particle size greatly decreased with the reduction of BDP solution flow rate, the increase of antisolvent flow rate and the increase of BDP concentration. However, the BDP particle size firstly decreased and then increased with the increase of the overall flow rate. Also, BDP solution as the injection phase could form the smaller BDP particles. 10 HPH cycles are enough to forming short rod-like particles. After spray drying, the BDP spherical aggregates with a 2-3 μm size could be achieved. They have an excellent aerosol performance, 2.8 and 1.4 times as many as raw BDP and vacuum-dried BDP particles, respectively. |
| 英文摘要: |
|
| 外单位作者单位: |
|
| 备注: |
|
关闭窗口 |
|
|
|
