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| 论文编号: |
122214O120120155 |
| 第一作者所在部门: |
708组 |
| 中文论文题目: |
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| 英文论文题目: |
Improved blood compatibility of Mg-1.0Zn-1.0Ca alloy by micro-arc oxidation
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| 论文题目英文: |
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| 作者: |
*张保平
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| 论文出处: |
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| 刊物名称: |
Journal of Biomedical Materials Research Part A
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| 年: |
2011
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| 卷: |
99 |
| 期: |
2 |
| 页: |
166-172 |
| 联系作者: |
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| 收录类别: |
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| 影响因子: |
2.147
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| 摘要: |
Magnesium and its alloys have been used in the recent development of lightweight, biodegradeable implant materials. However, the corrosion properties of magnesium limit its usefulness. In a previous study, a micro-arc oxidation (MAO) method was used to modify a Mg-1.0 wt % Zn-1.0 wt % Ca alloy surface, with the purpose of improving the corrosion resistance of Mg alloys. However, the blood compatibility of MAO-treated Mg alloy is unknown. Results of cytotoxicity assays with bone marrow-derived mesenchymal stem cells showed that extracts of MAO-treated alloy significantly decreased cytotoxicity compared to titanium alloy extract. Results of blood compatibility tests showed that the MAO group had a decreased hemolytic ratio (2.25%) compared to the untreated Mg alloy group (24.58%) (p < 0.001). The MAO group showed significantly shorter prothrombin and thrombin times and significantly longer activated partial thromboplastin time than the untreated Mg alloy group. Arachidonic acid- and adenosine diphosphate-induced platelet aggregations were significantly decreased by the untreated Mg alloy extract, and they were less affected by extract of MAO-treated Mg alloy. In conclusion, MAO-treated Mg-1.0 wt % Zn-1.0 wt % Ca alloy exhibits favorable blood compatibility characteristics and may be useful in the development of magnesium implant materials. |
| 英文摘要: |
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| 备注: |
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关闭窗口 |
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